Synthesis and antifungal activities of miltefosine analogs
نویسندگان
چکیده
منابع مشابه
Synthesis and antifungal activities of alanine-exchanged analogs of pradimicin A.
A series of pradimicin analogs were designed and synthesized to investigate the effect of the amino acid side chain on the antifungal activity. The alanine-exchanged analogs (3a approximately 3q) were synthesized from 4'-N-Cbz-pradimic acid by coupling with appropriate amino acids or their equivalents followed by deblocking. All the D-alpha-amino acid derivatives except D-proline analog, 3k ret...
متن کاملNew Benzimidazoles Derivatives: Synthesis, Characterization and Antifungal Activities
One of the most important goals in medicinal chemistry is the development of new heterocyclic compounds with pharmaceutical activity. Thus, a novel series of the derivatives of benzimidazole were synthesized and the structures of all the synthesized compounds have been confirmed by IR, 1 H- and 13C-NMR, Mass Spectroscopy and elemental analysis. The title compounds have been evaluated for antifu...
متن کاملSynthesis and nematocidal activities of jietacin A and its analogs.
Simple, efficient syntheses of jietacin A, a nematocidal antibiotic, and its analogs have been developed in order to study structure-activity relationships. A series of alpha,beta-unsaturated azoxy compounds was prepared from phenylselenomethyl azoxy compounds as key intermediates and its nematocidal activity was determined.
متن کاملSynthesis and antiproliferative activities of quebecol and its analogs.
Simple and efficient synthesis of quebecol and a number of its analogs was accomplished in five steps. The synthesized compounds were evaluated for antiproliferative activities against human cervix adenocarcinoma (HeLa), human ovarian carcinoma (SK-OV-3), human colon carcinoma (HT-29), and human breast adenocarcinoma (MCF-7) cancer cell lines. Among all the compounds, 7c, 7d, 7f, and 8f exhibit...
متن کاملThe synthesis and biological activities of some analogs of streptozotocin.
The aand /?-methyl glycosides (IV and V, respectively) of the antibiotic streptozotocin (I) have been synthesized. In addition, analogs involving epimeric changes at C2 (III) and C4 (II), and of two Q analogs, 3-/?-Dglucopyranosyl-1-methyl-l-nitrosourea (XXIII) and the corresponding Dgalactopyranosyl compound (XXV), together with their tetra-O-acetates (XXII and XXIV, respectively) have been pr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry Letters
سال: 2013
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2013.06.096